Able Training Logo
Korsakoff Syndrome

What is Korsakoff Syndrome?

What is Korsakoff Syndrome?

Korsakoff Syndrome is a long-term illness that shares many similarities with dementia. It is associated with a condition called Wernicke-Korsakoff Syndrome. 

In the realm of neurological disorders and dementia care, Korsakoff Syndrome is relatively unknown. Named after the Russian neuroscientist Sergei Korsakoff, this syndrome primarily affects individuals with a history of chronic alcoholism and severe thiamine deficiency.  Korsakoff Syndrome is characterised by significant memory loss and cognitive impairments that can greatly impact an individual’s daily life. 

In this short blog we will explore this lesser-known condition – looking at the causes, symptoms and potential treatments.

What causes Korsakoff Syndrome?

Korsakoff Syndrome is often seen as the chronic, second stage of an associated illness called Wernicke-Korsakoff Syndrome.  Wernicke–Korsakoff Syndrome is a condition that is similar to dementia, and is caused by drinking too much alcohol. Wernicke–Korsakoff syndrome has two separate stages of progression. The first stage is characterised by an individual who has acute, yet intense inflammation (swelling) of their brain. This is known as Wernicke’s Encephalopathy (WE).  If this condition remains untreated or isn’t treated quickly, the person may develop a more long-term, chronic condition called Korsakoff Syndrome (KS). This has many of the same symptoms of dementia. Over time, the damage to the brain becomes more difficult to recover from.

Because Korsakoff Syndrome often follows on from untreated Wernicke’s Encephalopathy, many people now refer to it as the combined condition Wernicke–Korsakoff Syndrome.

The leading cause of Korsakoff Syndrome is prolonged deficiency of thiamine, more commonly known as vitamin B1. Thiamine is an essential nutrient involved in the body’s energy production and brain function.  The body does not produce thiamine naturally, however most people can usually get all they need through food and a healthy diet.  Chronic alcoholism is the primary risk factor for developing Korsakoff Syndrome, as alcohol interferes with the body’s ability to adsorb and utilise thiamine effectively. Alcoholics may also have poor dietary habits and neglect proper nutrition, exacerbating thiamine deficiency and increasing the risk of developing the condition.

While alcohol is the primary factor, thiamine deficiency can also be caused through malnutrition, disordered eating, kidney dialysis, and taking high doses of diuretics.  Rarely, it can be caused through a genetic condition that results in difficulties absorbing the thiamine found in food.

What are the symptoms?

Korsakoff Syndrome is characterised by a combination of cognitive impairments and memory loss.  Because of this it is often described as an alcohol-related dementia (ARD), where the excessive intake of alcohol has led to alcohol related brain damage (ARBD).  The symptoms of alcohol-related dementia can vary from person to person; If a person with the condition has a brain scan, it will often show that some areas of the brain have shrunk much more than others. Alcohol particularly affects the frontal lobes of the brain. The frontal lobes control many diverse functions such as abstract reasoning and goal-oriented behaviour. They also play a role in personality expression and creativity. These skills are known collectively as executive functions.  Damage to the frontal lobes can result in personality and behavioural changes, problems regulating emotions and impulses, and difficulties with executive functioning like planning, problem solving and decision-making. 

The hallmark feature of Korsakoff Syndrome is anterograde amnesia: the inability to form new memories. Similar to other forms of dementia, individuals with KS struggle to remember recent events or learn and retain new information, often resorting to confabulation – fabricating stories to fill in memory gaps. This is not a deliberate deception on the part of the person with Korsakoff Syndrome – the brain unconsciously attempts to fill gaps in memory. 

Common symptoms include:

  • Retrograde amnesia: Difficulty recalling past memories before the onset of the syndrome.
  • Confusion and disorientation: Difficulty understanding the current time, place or circumstances.
  • Lack of insight: Individuals may remain unaware of their memory deficits and exhibit poor judgement.
  • Apathy and emotional changes: Loss of motivation, reduced interest in previously enjoyed activities, and changes in mood.
  • Executive dysfunction: Difficulties in planning, organising, problem-solving and decision-making.

Diagnosis and Treatment

Diagnosing Korsakoff Syndrome can be challenging; alcohol-related dementia symptoms are the same, or very similar, to those of other types of dementia, and individuals may be unaware of their memory problems or may attempt to conceal them.  Medical professionals typically conduct a thorough evaluation, including a comprehensive assessment of medical history, physical examination, neurological and psychological testing, and brain imaging scans to rule out other possible causes of illness.

The primary goal of treatment is to restore thiamine levels in the body and manage the symptoms.  Initially, high dose thiamine supplements are administered intravenously to rapidly replenish thiamine stores.  Once stabilised, oral supplements are prescribed to prevent further deficiency. Alcohol cessation is crucial to prevent ongoing thiamine depletion.

In addition to thiamine supplementation, rehabilitation programs play a vital role in helping individuals cope with cognitive impairments associated with Korsakoff Syndrome. Memory re-training, compensatory strategies, and cognitive exercises may be employed to enhance functional abilities.  Psychotherapy and support groups can aid in managing emotional and behavioural changes.

Through treatment, medication and lifestyle changes, the symptoms of Korsakoff Syndrome may gradually improve over time, but an estimated 25 percent of people will experience a permanent form of the condition. Wernicke’s Encephalopathy often occurs before Korsakoff Syndrome develops. If a person successfully receives early and swift treatment for Wernicke’s Encephalopathy, Korsakoff Syndrome may be prevented.


Korsakoff Syndrome is a complex neurological disorder resulting from chronic alcoholism and severe thiamine deficiency. Its impact on memory and cognition can significantly impair an individual’s quality of life.  Early diagnosis, prompt thiamine replacement and comprehensive rehabilitation efforts can help manage the symptoms and improve functional abilities.  Raising awareness about Korsakoff Syndrome (and its associated conditions) among healthcare professionals, families, carers and the community is crucial to ensure early intervention and support for those affected by this condition.

For further information regarding dementia, we offer an E-Learning course here as well as a course on substance misuse here. If you would prefer more in depth training, you can contact us via email or call us to book a face-to-face course.

Leave a Comment

Your email address will not be published. Required fields are marked *

Our website uses cookies to ensure you get the best experience. By using Able Training’s website, you accept our use of cookies